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KMID : 0388019940050030011
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Korean Journal Gynecologic Oncology and Colposcopy
1994 Volume.5 No. 3 p.11 ~ p.18
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Quantitative Analysis of p53 Expression in Carcinoma of the Uterine Cervix
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Abstract
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This study was performed to define the role of computerized quantitative analysis in evaluation for overexpression of p53 immunohistochemistry.
Total and labeled cells were counted automatically using commercially available software for color-image analysis. In 16 uterine cervical carcinomas, the p53 labeling index calculated by computerized quantitative analysis was 9.22±8.70% and by
visual
5.90±6.51%. The coefficient of variation with quantitative analysis was lower than that with visual analysis.
The present results suggest that the computerized quantitative analysis may be valuable in objective interpretaion of immunohistochemical expression of p53 and reliable than conventional ways f visual analysis.
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